The fuel islands at many truck stops can get very crowded. Most trucking companies have accounts with one or two truck stop chains and, after negotiating a specific price for diesel, require their drivers to fuel exclusively at supported locations. Truck stops near a large city, or on the east or west coasts, suffer from the most congestion at their fuel islands.

The retail stores in large truck stops offer a large selection of 12-volt DC products, such as coffee makers, combo television units, toaster ovens, and frying pans primarily targeted towards truck drivers, who often spend extended periods of time on the road. Such shops generally offer a wide selection of maps, road atlases, truck stop and freeway exit guides, truck accessories (such as CB radio equipment and hazmat placards), plus entertainment media such as movies, video games, music, and audiobooks. Increasingly, as interstate truck drivers have become a large market for satellite radio, these retail stores also sell various satellite radio receivers for both XM and Sirius XM as well as subscriptions to those services. Kiosks run by cellular phone providers are also common.